Bracket

Knockout play-off

SA Samsunspor 5 SH Shkëndija 0

First leg 1–0 Second leg 4–0

Celje 6 Drita 4

First leg 3–2 Second leg 3–2

NR NK Rijeka 4 Omonia 1

First leg 1–0 Second leg 3–1

LA Lausanne 2 SS Sigma Olomouc 3

First leg 1–1 Second leg 1–2

AF AC Fiorentina 5 JB Jagiellonia 4

First leg 3–0 Second leg 2–4

CP Crystal Palace 3 HZ Zrinjski 1

First leg 1–1 Second leg 2–0

AZ 4 NO Noah 1

First leg 0–1 Second leg 4–0

KuPS Kuopio 0 Lech Poznań 3

First leg 0–2 Second leg 0–1

Round of 16

Rayo Vallecano 3 SA Samsunspor 2

First leg 3–1 Second leg 0–1

Celje 2 AEK Athens 4

First leg 0–4 Second leg 2–0

NR NK Rijeka 2 ST RC Strasbourg 3

First leg 1–2 Second leg 1–1

SS Sigma Olomouc 0 FM FSV Mainz 05 2

First leg 0–0 Second leg 0–2

AF AC Fiorentina 4 RC Raków 2

First leg 2–1 Second leg 2–1

CP Crystal Palace 2 AL AEK Larnaka 1

First leg 0–0 Second leg 2–1

AZ 6 Sparta Praha 1

First leg 2–1 Second leg 4–0

Shakhtar 4 Lech Poznań 3

First leg 3–1 Second leg 1–2

Quarter-finals

Rayo Vallecano 4 AEK Athens 3

First leg 3–0 Second leg 1–3

ST RC Strasbourg 4 FM FSV Mainz 05 2

First leg 0–2 Second leg 4–0

AF AC Fiorentina 2 CP Crystal Palace 4

First leg 0–3 Second leg 2–1

AZ 2 Shakhtar 5

First leg 0–3 Second leg 2–2

Semi-finals

Rayo Vallecano 2 ST RC Strasbourg 0

First leg 1–0 Second leg 1–0

CP Crystal Palace 5 Shakhtar 2

First leg 3–1 Second leg 2–1

Final

Rayo Vallecano 0 CP Crystal Palace 1

Two legs: Knockout play-off, Round of 16, Quarter-finals, and Semi-finals.